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Predictors of lung function test severity and outcome in systemic sclerosis-associated interstitial lung disease

Author

Listed:
  • Noémie Le Gouellec
  • Alain Duhamel
  • Thierry Perez
  • Anne-Lise Hachulla
  • Vincent Sobanski
  • Jean-Baptiste Faivre
  • Sandrine Morell-Dubois
  • Marc Lambert
  • Pierre-Yves Hatron
  • Eric Hachulla
  • Hélène Béhal
  • Regis Matran
  • David Launay
  • Martine Remy-Jardin

Abstract

Systemic sclerosis-related interstitial lung disease (SSc-ILD) is the leading cause of death in SSc. In this study, we aimed to describe the baseline severity and evolution of forced vital capacity (FVC) and diffusing capacity for carbon monoxide (DLCO) in patients with SSc-ILD and to assess the baseline clinical, biological and high-resolution CT scan (HRCT) predictors of this evolution. Baseline and serial FVC and DLCO were collected in 75 SSc-ILD patients followed during 6.4±4.2 years (n = 557 individual data). FVC and DLCO evolution was modelled using a linear mixed model with random effect. During follow-up, FVC was stable while DLCO significantly decreased (-1.5±0.3%/year (p

Suggested Citation

  • Noémie Le Gouellec & Alain Duhamel & Thierry Perez & Anne-Lise Hachulla & Vincent Sobanski & Jean-Baptiste Faivre & Sandrine Morell-Dubois & Marc Lambert & Pierre-Yves Hatron & Eric Hachulla & Hélène , 2017. "Predictors of lung function test severity and outcome in systemic sclerosis-associated interstitial lung disease," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0181692
    DOI: 10.1371/journal.pone.0181692
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