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Non-invasive prediction of preterm birth in women with cervical insufficiency or an asymptomatic short cervix (≤25 mm) by measurement of biomarkers in the cervicovaginal fluid

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  • Ha-Na Yoo
  • Kyo Hoon Park
  • Eun Young Jung
  • Yu Mi Kim
  • Song Yi Kook
  • Se Jeong Jeon

Abstract

Objective: To determine whether various proteins in the cervicovaginal fluid (CVF) known to be involved in immune regulation, alone or in combination with clinical risk factors, can predict spontaneous preterm delivery (SPTD) in women with cervical insufficiency or a short cervix (≤25 mm). Methods: This retrospective cohort study included 62 asymptomatic women with cervical insufficiency (n = 27) or an asymptomatic short cervix (n = 35) at 18–27 weeks. CVF swab samples were taken for assays of vitamin D binding protein (VDBP), interleukin (IL)-8, matrix metalloproteinases (MMP)-9, tissue inhibitor of metalloproteinases (TIMP)-1, and Dickkopf-related protein 3 (DKK3) before cervical examination, and maternal blood was collected for the determination of the C-reactive protein (CRP) level. The primary outcome measurement was SPTD at

Suggested Citation

  • Ha-Na Yoo & Kyo Hoon Park & Eun Young Jung & Yu Mi Kim & Song Yi Kook & Se Jeong Jeon, 2017. "Non-invasive prediction of preterm birth in women with cervical insufficiency or an asymptomatic short cervix (≤25 mm) by measurement of biomarkers in the cervicovaginal fluid," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0180878
    DOI: 10.1371/journal.pone.0180878
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