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Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy

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  • Shih-Hung Yang
  • Jen-Chieh Lee
  • Jhe-Cyuan Guo
  • Sung-Hsin Kuo
  • Yu-Wen Tien
  • Ting-Chun Kuo
  • Ann-Lii Cheng
  • Kun-Huei Yeh

Abstract

This study evaluated the prognostic roles of murine double minute 2 (MDM2) and p53 in pancreatic cancer patients treated with gemcitabine-based chemotherapy. A total of 137 advanced or recurrent adenocarcinoma patients who were treated with gemcitabine-based palliative chemotherapy were reviewed, selected from 957 patients with pancreatic malignancy between 2008 and 2013 at our hospital. Immunohistochemical staining for MDM2 and p53 with formalin-fixed, paraffin-embedded tumor tissues was independently reviewed. Nuclear or cytoplasmic expression of MDM2 and p53 was found in tumor cells of 30 (21.9%) and 71 (51.8%) patients, respectively. Patients with MDM2 expression had shorter median overall survival (OS) (3.7 vs 5.8 mo; P = .048) and median progression-free survival (PFS) (1.5 vs 2.5 mo; P

Suggested Citation

  • Shih-Hung Yang & Jen-Chieh Lee & Jhe-Cyuan Guo & Sung-Hsin Kuo & Yu-Wen Tien & Ting-Chun Kuo & Ann-Lii Cheng & Kun-Huei Yeh, 2017. "Association of MDM2 expression with shorter progression-free survival and overall survival in patients with advanced pancreatic cancer treated with gemcitabine-based chemotherapy," PLOS ONE, Public Library of Science, vol. 12(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0180628
    DOI: 10.1371/journal.pone.0180628
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