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Dynamic changes of anterior segment in patients with different stages of primary angle-closure in both eyes and normal subjects

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  • Jialiu Lin
  • Zhonghao Wang
  • Chuchen Chung
  • Jianan Xu
  • Miaomiao Dai
  • Jingjing Huang

Abstract

Purpose: To compare changes in anterior segment parameters under light and dark (light-to-dark) conditions among eyes with chronic primary angle-closure glaucoma (CPACG), fellow eyes with confirmed or suspect primary angle-closure (PAC or PACS), and age-matched healthy eyes. Methods: Consecutive patients with CPACG in one eye and PAC/PACS in the fellow eye, as well as age-matched healthy subjects were recruited. Anterior segment optical coherence tomography measurements were conducted under light and dark conditions, and anterior chamber, lens, and iris parameters compared. Demographic and biometric factors associated with light-to-dark change in iris area were analyzed by linear regression. Results: Fifty-seven patients (mean age 59.6±8.9 years) and 30 normal subjects matched for age (60.6±9.3 years) and sex ratio were recruited. In regards to differences under light–to-dark conditions, angle opening distance at 500 μm (AOD500μm) and iris area during light-to-dark transition were smaller in CPACG eyes than fellow PACS/PAC eyes and normal eyes (P

Suggested Citation

  • Jialiu Lin & Zhonghao Wang & Chuchen Chung & Jianan Xu & Miaomiao Dai & Jingjing Huang, 2017. "Dynamic changes of anterior segment in patients with different stages of primary angle-closure in both eyes and normal subjects," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0177769
    DOI: 10.1371/journal.pone.0177769
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    1. Zhonghao Wang & Xuanwei Liang & Ziqiang Wu & Jialiu Lin & Jingjing Huang, 2015. "A Novel Method for Measuring Anterior Segment Area of the Eye on Ultrasound Biomicroscopic Images Using Photoshop," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-13, March.
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