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Serum folate concentration and the incidence of lung cancer

Author

Listed:
  • Katarzyna Durda
  • Krzysztof Kąklewski
  • Satish Gupta
  • Michał Szydłowski
  • Piotr Baszuk
  • Katarzyna Jaworska-Bieniek
  • Grzegorz Sukiennicki
  • Katarzyna Kaczmarek
  • Piotr Waloszczyk
  • Steven Narod
  • Jan Lubiński
  • Anna Jakubowska

Abstract

Background: Lung cancer is a leading cause of cancer-related mortality globally. Folate helps to maintain DNA integrity and to regulate gene expression. Serum folate levels may affect the risk of several cancers, including lung cancer. In this study we evaluated the association between serum folate concentration and variations in genes involved in folate metabolism with lung cancer incidence in Poland. Methods: The study included 366 lung cancer patients and 366 control subjects. We measured serum folate concentration and genotyped six variants in MTHFR, MTR and MTRR genes. The odds ratios of being diagnosed with lung cancer were calculated using conditional univariable and multivariable logistic regression with respect to folate level and genotypes. Results: The mean serum folate level was lower in lung cancer cases than in control group (20.07 nmol/l vs. 22.52 nmol/l, p = 0.002). The odds ratio for lung cancer declined with increasing serum content of the folate. The folate concentration of >25.71 nmol/l (IVth quartile) in comparison to

Suggested Citation

  • Katarzyna Durda & Krzysztof Kąklewski & Satish Gupta & Michał Szydłowski & Piotr Baszuk & Katarzyna Jaworska-Bieniek & Grzegorz Sukiennicki & Katarzyna Kaczmarek & Piotr Waloszczyk & Steven Narod & Ja, 2017. "Serum folate concentration and the incidence of lung cancer," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-10, May.
    • Handle: RePEc:plo:pone00:0177441
    DOI: 10.1371/journal.pone.0177441
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