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Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk factor

Author

Listed:
  • Joshi Tsutsumi
  • Kosuke Minai
  • Makoto Kawai
  • Kazuo Ogawa
  • Yasunori Inoue
  • Satoshi Morimoto
  • Toshikazu Tanaka
  • Tomohisa Nagoshi
  • Takayuki Ogawa
  • Michihiro Yoshimura

Abstract

Background/Objectives: Obesity is believed to be one of the major risk factors for cardiovascular disease in Western countries. However, the effects of obesity should be continuously examined in the Japanese population because the average bodily habitus differs among countries. In this study, we collectively examined the significance of obesity and obesity-triggered risk factors including the low reactivity of B-type natriuretic peptide (BNP), for ischemic heart disease (IHD) in Japanese patients. Methods and results: The study patients consisted of 1252 subjects (IHD: n = 970; non-IHD: n = 282). Multiple logistic regression analysis revealed that dyslipidemia, hypertension, diabetes, and the low reactivity of BNP were significant risk factors for IHD, but body mass index (BMI) was not. A theoretical path model was proposed by positioning BMI at the top of the hierarchical model. Exploratory factor analysis revealed that BMI did not play a causative role in IHD (P = NS). BMI was causatively linked to other risk factors (P

Suggested Citation

  • Joshi Tsutsumi & Kosuke Minai & Makoto Kawai & Kazuo Ogawa & Yasunori Inoue & Satoshi Morimoto & Toshikazu Tanaka & Tomohisa Nagoshi & Takayuki Ogawa & Michihiro Yoshimura, 2017. "Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type natriuretic peptide as an intervening risk facto," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0177327
    DOI: 10.1371/journal.pone.0177327
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    References listed on IDEAS

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    1. Jean-Pierre Després & Isabelle Lemieux, 2006. "Abdominal obesity and metabolic syndrome," Nature, Nature, vol. 444(7121), pages 881-887, December.
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