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Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study

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  • Chao Yang
  • Shujuan Yang
  • Weiwei Xu
  • Junhui Zhang
  • Wenguang Fu
  • Chunhong Feng

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a common chronic disease associated with high levels of serum uric acid (SUA). However, whether this relationship applies in obese subjects has been unclear, and no cohort study has previously been conducted in non-obese subjects. We therefore performed a retrospective cohort study among employees of seven companies in China to investigate whether hyperuricemia was independently associated with NAFLD in obese and non-obese subjects, respectively. A total of 2383 initially NAFLD-free subjects were followed up for four years, and 15.2% (363/2383) developed NAFLD. Hyperuricemia subjects had a higher cumulative incidence than did those with normouricemia (29.0% vs. 12.9%, P

Suggested Citation

  • Chao Yang & Shujuan Yang & Weiwei Xu & Junhui Zhang & Wenguang Fu & Chunhong Feng, 2017. "Association between the hyperuricemia and nonalcoholic fatty liver disease risk in a Chinese population: A retrospective cohort study," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0177249
    DOI: 10.1371/journal.pone.0177249
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