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Influence of eye biometrics and corneal micro-structure on noncontact tonometry

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  • Danilo A Jesus
  • Małgorzata Majewska
  • Patrycja Krzyżanowska-Berkowska
  • D Robert Iskander

Abstract

Purpose: Tonometry is widely used as the main screening tool supporting glaucoma diagnosis. Still, its accuracy could be improved if full knowledge about the variation of the corneal biomechanical properties was available. In this study, Optical Coherence Tomography (OCT) speckle statistics are used to infer the organisation of the corneal micro-structure and hence, to analyse its influence on intraocular pressure (IOP) measurements. Methods: Fifty-six subjects were recruited for this prospective study. Macro and micro-structural corneal parameters as well as subject age were considered. Macro-structural analysis included the parameters that are associated with the ocular anatomy, such as central corneal thickness (CCT), corneal radius, axial length, anterior chamber depth and white-to-white corneal diameter. Micro-structural parameters which included OCT speckle statistics were related to the internal organisation of the corneal tissue and its physiological changes during lifetime. The corneal speckle obtained from OCT was modelled with the Generalised Gamma (GG) distribution that is characterised with a scale parameter and two shape parameters. Results: In macro-structure analysis, only CCT showed a statistically significant correlation with IOP (R2 = 0.25, p

Suggested Citation

  • Danilo A Jesus & Małgorzata Majewska & Patrycja Krzyżanowska-Berkowska & D Robert Iskander, 2017. "Influence of eye biometrics and corneal micro-structure on noncontact tonometry," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-15, May.
    • Handle: RePEc:plo:pone00:0177180
    DOI: 10.1371/journal.pone.0177180
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    References listed on IDEAS

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    1. Akram Abdelazim Joda & Mir Mohi Sefat Shervin & Daniel Kook & Ahmed Elsheikh, 2016. "Development and validation of a correction equation for Corvis tonometry," Computer Methods in Biomechanics and Biomedical Engineering, Taylor & Francis Journals, vol. 19(9), pages 943-953, July.
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    Cited by:

    1. Marcela Niemczyk & Monika E Danielewska & Malgorzata A Kostyszak & Daniel Lewandowski & D Robert Iskander, 2021. "The effect of intraocular pressure elevation and related ocular biometry changes on corneal OCT speckle distribution in porcine eyes," PLOS ONE, Public Library of Science, vol. 16(3), pages 1-18, March.

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