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Associations between MRI features versus knee pain severity and progression: Data from the Vancouver Longitudinal Study of Early Knee Osteoarthritis

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  • Eric C Sayre
  • Ali Guermazi
  • John M Esdaile
  • Jacek A Kopec
  • Joel Singer
  • Anona Thorne
  • Savvas Nicolaou
  • Jolanda Cibere

Abstract

Objective: To determine associations between features of osteoarthritis (OA) on MRI and knee pain severity and knee pain progression. Design: Baseline, 3.3- and 7.5-year assessments were performed for 122 subjects with baseline knee pain (age 40–79), sample-weighted for population (with knee pain) representativeness. MRIs were scored for: osteophytes (0:absent to 3:large); cartilage (0:normal to 4:full thickness defect; 0/1 collapsed); subchondral sclerosis (0:none to 3:>50% of site), subchondral cyst (0:absent to 3:severe), bone marrow lesions (0:none to 3:≥50% of site); and meniscus (0:normal to 3:maceration/resection), in 6–8 regions each. Per feature, scores were averaged across regions. Effusion/synovitis (0:absent to 3:severe) was analyzed as ≥2 vs.

Suggested Citation

  • Eric C Sayre & Ali Guermazi & John M Esdaile & Jacek A Kopec & Joel Singer & Anona Thorne & Savvas Nicolaou & Jolanda Cibere, 2017. "Associations between MRI features versus knee pain severity and progression: Data from the Vancouver Longitudinal Study of Early Knee Osteoarthritis," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-12, May.
    • Handle: RePEc:plo:pone00:0176833
    DOI: 10.1371/journal.pone.0176833
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