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Neural substrate of posterior left atrium: A novel modulation for inducibility and remodeling of atrial fibrillation in canine

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  • Mu Qin
  • Li Li
  • Xu Liu
  • Tao Liu
  • Shao Bo Shi

Abstract

Background: The neural mechanism of posterior left atrium (PLA) for genesis of atrial fibrillation has not been completely elucidated. We sought to assess the contribution of PLA denervation on atrial fibrillation (AF) inducibility and atrial remodeling. Methods and results: After left thoracotomy in anesthetized dogs (n = 32), electrode catheters were attached to the PLA, left atrial roof, left pulmonary vein and left atrial appendage. Experiment 1 (n = 16): Vagal stimulation (VS group, n = 8) led to more pronounced ERP shortening in PLA than in other sites (CTL:71±7 ms vs VS: 52±6 ms, P 0.05). In addition, domain frequency (DF) of VS-induced AF waveform was not affected by atropine alone, while selective double autonomic blockade at PLA significantly decreased DF at all sites (P

Suggested Citation

  • Mu Qin & Li Li & Xu Liu & Tao Liu & Shao Bo Shi, 2017. "Neural substrate of posterior left atrium: A novel modulation for inducibility and remodeling of atrial fibrillation in canine," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-13, May.
    • Handle: RePEc:plo:pone00:0176626
    DOI: 10.1371/journal.pone.0176626
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