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Circulating microRNAs in patients with intracranial aneurysms

Author

Listed:
  • John A L Meeuwsen
  • Femke N G van ´t Hof
  • Wouter van Rheenen
  • Gabriel J E Rinkel
  • Jan H Veldink
  • Ynte M Ruigrok

Abstract

Introduction: We compared circulating microRNA (miRNA) levels in plasma of patients with intracranial aneurysms (IA) to those of controls as a first step towards finding potential biomarkers for individuals at high risk of IA development and its subsequent rupture. Patients and methods: Using a PCR array we measured 370 miRNAs in plasma of 15 patients with prior aneurysmal subarachnoid hemorrhage (aSAH), of whom 11 had an additional unruptured IA (UIA), and of 15 controls. MiRNAs with a difference in levels with an absolute fold change (FC) > 1.2 and p 1.2 and p

Suggested Citation

  • John A L Meeuwsen & Femke N G van ´t Hof & Wouter van Rheenen & Gabriel J E Rinkel & Jan H Veldink & Ynte M Ruigrok, 2017. "Circulating microRNAs in patients with intracranial aneurysms," PLOS ONE, Public Library of Science, vol. 12(5), pages 1-11, May.
    • Handle: RePEc:plo:pone00:0176558
    DOI: 10.1371/journal.pone.0176558
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