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Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis

Author

Listed:
  • Satoshi Ito
  • Tomohisa Nagoshi
  • Kosuke Minai
  • Yusuke Kashiwagi
  • Hiroshi Sekiyama
  • Akira Yoshii
  • Haruka Kimura
  • Yasunori Inoue
  • Kazuo Ogawa
  • Toshikazu D Tanaka
  • Takayuki Ogawa
  • Makoto Kawai
  • Michihiro Yoshimura

Abstract

Objective: Although glucose-insulin-potassium (GIK) therapy ought to be beneficial for ischemic heart disease in general, variable outcomes in many clinical trials of GIK in acute coronary syndrome (ACS) had a controversial impact. This study was designed to examine whether “insulin resistance” is involved in ACS and to clarify other potential intrinsic compensatory mechanisms for GIK tolerance through highly statistical procedure. Methods and results: We compared the degree of insulin resistance during ACS attack and remission phase after treatment in individual patients (n = 104). During ACS, homeostasis model assessment of insulin resistance (HOMA-IR) values were significantly increased (P

Suggested Citation

  • Satoshi Ito & Tomohisa Nagoshi & Kosuke Minai & Yusuke Kashiwagi & Hiroshi Sekiyama & Akira Yoshii & Haruka Kimura & Yasunori Inoue & Kazuo Ogawa & Toshikazu D Tanaka & Takayuki Ogawa & Makoto Kawai &, 2017. "Possible increase in insulin resistance and concealed glucose-coupled potassium-lowering mechanisms during acute coronary syndrome documented by covariance structure analysis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-15, April.
    • Handle: RePEc:plo:pone00:0176435
    DOI: 10.1371/journal.pone.0176435
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