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The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis

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  • Yong-chao Qiao
  • Yin-ling Chen
  • Yan-hong Pan
  • Fang Tian
  • Yan Xu
  • Xiao-xi Zhang
  • Hai-lu Zhao

Abstract

Objective: The aim of this study was used meta-analysis to investigate changes of serum tumor necrosis factor-alpha (TNF-α) in patients with type 1 diabetes mellitus (T1DM). Methods: Relevant literatures were identified from PubMed, Cochrane Library, CNKI, WanFang and Chinese-Cqvip databases (published from January 1, 1999 to September 30, 2016). Eligible reports were included for pooled analysis of serum TNF-α level and subgroup analysis was performed in relation with age, disease duration and ethnicity. Results: A total of 23 articles (1631 T1DM cases, 1429 healthy controls) were included for this meta-analysis. Compared with the controls, the patients had significantly increased serum TNF-α level (P

Suggested Citation

  • Yong-chao Qiao & Yin-ling Chen & Yan-hong Pan & Fang Tian & Yan Xu & Xiao-xi Zhang & Hai-lu Zhao, 2017. "The change of serum tumor necrosis factor alpha in patients with type 1 diabetes mellitus: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-14, April.
    • Handle: RePEc:plo:pone00:0176157
    DOI: 10.1371/journal.pone.0176157
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