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Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study

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  • Li-Wei Chen
  • Fang-Ping Chen
  • Chia-Wen Hsieh
  • Sheng-Fong Kuo
  • Rong-Nan Chien

Abstract

Helicobacter pylori (H. pylori) infection may induce inflammatory cytokines or adipokines that influence bone turnover and bone fracture risk. This study aimed to evaluate the association among H. pylori infection, adipokines, and 10-year fracture risk using the Fracture Risk Assessment Tool scale. From August 2013 to February 2016, a community-based cohort was surveyed by Keelung Chang-Gung Memorial Hospital. Subjects were included if they were older than 40 years and not pregnant. All participants underwent a standardized questionnaire survey, physical examination, urea breath test, and blood tests. A total of 2,689 participants (1,792 women) were included in this cross-sectional study. In both sexes, participants with a high fracture risk were older and had higher adiponectin values than participants without a high fracture risk (mean age, female: 72.9 ± 5.6 vs. 55.8 ± 7.3 years, P

Suggested Citation

  • Li-Wei Chen & Fang-Ping Chen & Chia-Wen Hsieh & Sheng-Fong Kuo & Rong-Nan Chien, 2017. "Analysis of the associations among Helicobacter pylori infection, adiponectin, leptin, and 10-year fracture risk using the fracture risk assessment tool: A cross-sectional community-based study," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0175365
    DOI: 10.1371/journal.pone.0175365
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