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Establishment of a tear protein biomarker panel differentiating between Graves’ disease with or without orbitopathy

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  • Cecilie Aass
  • Ingrid Norheim
  • Erik Fink Eriksen
  • Ellen Charlotte Børnick
  • Per Medbøe Thorsby
  • Milaim Pepaj

Abstract

Background: Graves’ orbitopathy (GO) is an autoimmune inflammatory ocular complication and one of the most frequent manifestations of Graves’ disease (GD). Clinical judgment of GO is subjective sometimes leading to clinical and therapeutic challenges. Better tools to diagnose this severe complication are warranted. Patients and methods: The aim of the present study was to evaluate tear levels of LYZ, LACRT and AZGP1 in GD patients with or without GO, as possible biomarkers for GO. Tear samples were collected from GD patients with moderate-to-severe GO (n = 21) and no clinical signs of GO (n = 21). Additionally, 18 GD patients with mild GO and 9 patients without GO were included in a further part of the study. Results: Tear levels of LYZ (p

Suggested Citation

  • Cecilie Aass & Ingrid Norheim & Erik Fink Eriksen & Ellen Charlotte Børnick & Per Medbøe Thorsby & Milaim Pepaj, 2017. "Establishment of a tear protein biomarker panel differentiating between Graves’ disease with or without orbitopathy," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-12, April.
    • Handle: RePEc:plo:pone00:0175274
    DOI: 10.1371/journal.pone.0175274
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