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Impact of meningitis on intelligence and development: A systematic review and meta-analysis

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  • Deborah Christie
  • Harunor Rashid
  • Haitham El-Bashir
  • Faye Sweeney
  • Tim Shore
  • Robert Booy
  • Russell M Viner

Abstract

Background: We undertook a systematic review and meta-analysis to address the question “what is the impact of meningitis on IQ and development.” Methods: Search: conducted using standardized search terms across Medline, PsychInfo and EMBASE to 06/2014. Eligibility: human studies of any infectious aetiology of meningitis reporting IQ or infant developmental age or stage outcomes. Quality: Centre for Evidence Based Medicine, Oxford, quality tools. Analysis: random effects meta-analysis by organism. Results: 39 studies were included in the review, 34 providing data on IQ (2015 subjects) and 12 on developmental delay (382 subjects). Across all bacterial organisms, meningitis survivors had a mean IQ 5.50 (95% CI: -7.19, -3.80; I2 = 47%, p = 0.02) points lower than controls. IQ was significantly lower than controls for Neisseria meningitides (NM: 5 points) and Haemophilus influenzae b (Hib: 6 points) but not in viral meningitis, with only single studies included for Streptococcus pneumoniae (SP) and group B streptococcus (GBS). The pooled relative risk (RR) for low IQ (IQ

Suggested Citation

  • Deborah Christie & Harunor Rashid & Haitham El-Bashir & Faye Sweeney & Tim Shore & Robert Booy & Russell M Viner, 2017. "Impact of meningitis on intelligence and development: A systematic review and meta-analysis," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-14, August.
    • Handle: RePEc:plo:pone00:0175024
    DOI: 10.1371/journal.pone.0175024
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