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High MELD score and extended operating time predict prolonged initial ICU stay after liver transplantation and influence the outcome

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  • Panagiota Stratigopoulou
  • Andreas Paul
  • Dieter P Hoyer
  • Stylianos Kykalos
  • Fuat H Saner
  • Georgios C Sotiropoulos

Abstract

Background: The aim of the present study is to determine the incidence of a prolonged (>3 days) initial ICU-stay after liver transplantation (LT) and to identify risk factors for it. Patients and methods: We retrospectively analyzed data of adult recipients who underwent deceased donor first-LT at the University Hospital Essen between 11/2003 and 07/2012 and showed a primary graft function. Results: Of the 374 recipients, 225 (60.16%) had prolonged ICU-stay. On univariate analysis, donor INR, high doses of vasopressors, “rescue-offer” grafts, being hospitalized at transplant, high urgency cases, labMELD, alcoholic cirrhosis, being on renal dialysis and length of surgery were associated with prolonged ICU-stay. After multivariate analysis, only the labMELD and the operation’s length were independently correlated with prolonged ICU-stay. Cut-off values for these variables were 19 and 293.5 min, respectively. Hospital stay was longer for patients with a prolonged initial ICU-stay (p

Suggested Citation

  • Panagiota Stratigopoulou & Andreas Paul & Dieter P Hoyer & Stylianos Kykalos & Fuat H Saner & Georgios C Sotiropoulos, 2017. "High MELD score and extended operating time predict prolonged initial ICU stay after liver transplantation and influence the outcome," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-16, March.
  • Handle: RePEc:plo:pone00:0174173
    DOI: 10.1371/journal.pone.0174173
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