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Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy

Author

Listed:
  • Atsushi Takahashi
  • Soichi Kono
  • Akira Wada
  • Sachie Oshima
  • Kazumichi Abe
  • Hiromichi Imaizumi
  • Masashi Fujita
  • Manabu Hayashi
  • Ken Okai
  • Itaru Miura
  • Hirooki Yabe
  • Hiromasa Ohira

Abstract

Patients with non-alcoholic fatty liver disease (NAFLD) have impaired health-related quality of life including physical and mental state. Near-infrared spectroscopy (NIRS) is a useful tool for evaluation of brain activity and depressive state. This study aimed to determine the brain activity of female NAFLD patients using NIRS. Cerebral oxygenated hemoglobin (oxy-Hb) concentration during a verbal fluency task (VFT) was measured using NIRS in 24 female NAFLD patients and 15 female healthy controls. The Center for Epidemiologic Studies Depression Scale (CES-D) questionnaire was administered to both groups before NIRS. There was no significant difference in CES-D score between groups. However, the oxy-Hb concentration and number of words during the VFT were less in NAFLD compared to healthy controls. The mean value of oxy-Hb concentration during 0–60 s VFT in the frontal lobe was also smaller in NAFLD patients compared to healthy controls (0.082 ± 0.126 vs. 0.183 ± 0.145, P

Suggested Citation

  • Atsushi Takahashi & Soichi Kono & Akira Wada & Sachie Oshima & Kazumichi Abe & Hiromichi Imaizumi & Masashi Fujita & Manabu Hayashi & Ken Okai & Itaru Miura & Hirooki Yabe & Hiromasa Ohira, 2017. "Reduced brain activity in female patients with non-alcoholic fatty liver disease as measured by near-infrared spectroscopy," PLOS ONE, Public Library of Science, vol. 12(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0174169
    DOI: 10.1371/journal.pone.0174169
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