IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0174050.html
   My bibliography  Save this article

Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis

Author

Listed:
  • Pablo Orellano
  • Nancy Quaranta
  • Julieta Reynoso
  • Brenda Balbi
  • Julia Vasquez

Abstract

Background: Several observational studies have suggested that outdoor air pollution may induce or aggravate asthma. However, epidemiological results are inconclusive due to the presence of numerous moderators which influence this association. The goal of this study was to assess the relationship between outdoor air pollutants and moderate or severe asthma exacerbations in children and adults through a systematic review and multilevel meta-analysis. Material and methods: We searched studies published in English on PubMed, Scopus, and Google Scholar between January 2000 and October 2016. Studies following a case-crossover design with records of emergency departments and/or hospital admissions as a surrogate of moderate or severe asthma exacerbations were selected. A multilevel meta-analysis was employed, taking into account the potential clustering effects within studies examining more than one lag. Odds ratios (ORs) and 95% confidence intervals were estimated. A subgroup analysis in children aged 0 to 18 years and a sensitivity analysis based on the quality of the included studies as defined in the Newcastle-Ottawa Scale were performed. Publication bias was evaluated through visual inspection of funnel plots and by a complementary search of grey literature. (Prospero Registration number CRD42015032323). Results: Database searches retrieved 208 records, and finally 22 studies were selected for quantitative analysis. All pollutants except SO2 and PM10 showed a significant association with asthma exacerbations (NO2: 1.024; 95% CI: 1.005,1.043, SO2: 1.039; 95% CI: 0.988,1.094), PM10: 1.024; 95% CI: 0.995,1.053, PM2.5: 1.028; 95% CI: 1.009,1.047, CO: 1.045; 95% CI: 1.005,1.086, O3: 1.032; 95% CI: 1.005,1.060. In children, the association was significant for NO2, SO2 and PM2.5. Conclusion: This meta-analysis provides evidence of the association between selected air pollutants and asthma exacerbations for different lags.

Suggested Citation

  • Pablo Orellano & Nancy Quaranta & Julieta Reynoso & Brenda Balbi & Julia Vasquez, 2017. "Effect of outdoor air pollution on asthma exacerbations in children and adults: Systematic review and multilevel meta-analysis," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-15, March.
    • Handle: RePEc:plo:pone00:0174050
    DOI: 10.1371/journal.pone.0174050
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174050
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0174050&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0174050?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Valentina Fainardi & Carlo Caffarelli & Barbara Maria Bergamini & Loretta Biserna & Paolo Bottau & Elena Corinaldesi & Arianna Dondi & Martina Fornaro & Battista Guidi & Francesca Lombardi & Maria Sol, 2021. "Management of Children with Acute Asthma Attack: A RAND/UCLA Appropriateness Approach," IJERPH, MDPI, vol. 18(23), pages 1-19, December.
    2. Agarwal, Avinash Kumar & Mustafi, Nirendra Nath, 2021. "Real-world automotive emissions: Monitoring methodologies, and control measures," Renewable and Sustainable Energy Reviews, Elsevier, vol. 137(C).
    3. Angelica I. Tiotiu & Plamena Novakova & Denislava Nedeva & Herberto Jose Chong-Neto & Silviya Novakova & Paschalis Steiropoulos & Krzysztof Kowal, 2020. "Impact of Air Pollution on Asthma Outcomes," IJERPH, MDPI, vol. 17(17), pages 1-29, August.
    4. Ching-Yen Kuo & Chin-Kan Chan & Chiung-Yi Wu & Dinh-Van Phan & Chien-Lung Chan, 2019. "The Short-Term Effects of Ambient Air Pollutants on Childhood Asthma Hospitalization in Taiwan: A National Study," IJERPH, MDPI, vol. 16(2), pages 1-13, January.
    5. Hai Thanh Phan & Giap Van Vu & Giang Thu Vu & Giang Hai Ha & Hai Quang Pham & Carl A. Latkin & Bach Xuan Tran & Cyrus S.H. Ho & Roger C.M. Ho, 2020. "Global Mapping of Research Trends on Interventions to Improve Health-Related Quality of Life in Asthma Patients," IJERPH, MDPI, vol. 17(10), pages 1-14, May.
    6. Ching-Yen Kuo & Ren-Hao Pan & Chin-Kan Chan & Chiung-Yi Wu & Dinh-Van Phan & Chien-Lung Chan, 2018. "Application of a Time-Stratified Case-Crossover Design to Explore the Effects of Air Pollution and Season on Childhood Asthma Hospitalization in Cities of Differing Urban Patterns: Big Data Analytics ," IJERPH, MDPI, vol. 15(4), pages 1-15, March.
    7. Hong-Ren Yu & Chun-Hung Richard Lin & Jui-Hsiu Tsai & Yun-Ting Hsieh & Ti-An Tsai & Chang-Ku Tsai & Yi-Chen Lee & Ta-Yu Liu & Chih-Min Tsai & Chih-Cheng Chen & Chih-Hao Chang & Te-Yao Hsu & Chen-Kuang, 2020. "A Multifactorial Evaluation of the Effects of Air Pollution and Meteorological Factors on Asthma Exacerbation," IJERPH, MDPI, vol. 17(11), pages 1-13, June.
    8. Xiaowei Xu & Daxin Dong & Yilun Wang & Shiying Wang, 2019. "The Impacts of Different Air Pollutants on Domestic and Inbound Tourism in China," IJERPH, MDPI, vol. 16(24), pages 1-15, December.
    9. Hicham Ajami & Hamid Mcheick & Catherine Laprise, 2022. "First Steps of Asthma Management with a Personalized Ontology Model," Future Internet, MDPI, vol. 14(7), pages 1-13, June.
    10. Fabio Barbone & Dolores Catelan & Riccardo Pistelli & Gabriele Accetta & Daniele Grechi & Franca Rusconi & Annibale Biggeri, 2019. "A Panel Study on Lung Function and Bronchial Inflammation among Children Exposed to Ambient SO 2 from an Oil Refinery," IJERPH, MDPI, vol. 16(6), pages 1-18, March.
    11. Rie Masuda & Paul Lanier & Ellen Peisner-Feinberg & Hideki Hashimoto, 2021. "A Quasi-Experimental Study of the Effects of Pre-Kindergarten Education on Pediatric Asthma," IJERPH, MDPI, vol. 18(19), pages 1-18, October.
    12. Sol Yu & Sujung Park & Choon-Sik Park & Sungroul Kim, 2018. "Association between the Ratio of FEV 1 to FVC and the Exposure Level to Air Pollution in Neversmoking Adult Refractory Asthmatics Using Data Clustered by Patient in the Soonchunhyang Asthma Cohort Dat," IJERPH, MDPI, vol. 15(11), pages 1-11, October.
    13. Sarah J. D. Nauwelaerts & Koen De Cremer & Natalia Bustos Sierra & Mathieu Gand & Dirk Van Geel & Maud Delvoye & Els Vandermassen & Jordy Vercauteren & Christophe Stroobants & Alfred Bernard & Nelly D, 2022. "Assessment of the Feasibility of a Future Integrated Larger-Scale Epidemiological Study to Evaluate Health Risks of Air Pollution Episodes in Children," IJERPH, MDPI, vol. 19(14), pages 1-28, July.
    14. Zhuanlan Sun & Demi Zhu, 2019. "Exposure to outdoor air pollution and its human health outcomes: A scoping review," PLOS ONE, Public Library of Science, vol. 14(5), pages 1-18, May.
    15. Hiroshi Yamaguchi & Kandai Nozu & Shinya Ishiko & Atsushi Kondo & Takeshi Ninchoji & China Nagano & Hiroki Takeda & Ai Unzaki & Kazuto Ishibashi & Ichiro Morioka & Hiroaki Nagase & Kazumoto Iijima & A, 2021. "Impact of the State of Emergency during the COVID-19 Pandemic in 2020 on Asthma Exacerbations among Children in Kobe City, Japan," IJERPH, MDPI, vol. 18(21), pages 1-19, October.
    16. Wojciech Nazar & Marek Niedoszytko, 2022. "Air Pollution in Poland: A 2022 Narrative Review with Focus on Respiratory Diseases," IJERPH, MDPI, vol. 19(2), pages 1-20, January.
    17. Woohyun Yoo, 2022. "Addressing the Social Determinants of Health in South Korea: Moderating Role of mHealth Technologies," IJERPH, MDPI, vol. 19(3), pages 1-13, February.
    18. Sandie Ha & Carrie Nobles & Jenna Kanner & Seth Sherman & Seung-Hyun Cho & Neil Perkins & Andrew Williams & William Grobman & Joseph Biggio & Akila Subramaniam & Marion Ouidir & Zhen Chen & Pauline Me, 2020. "Air Pollution Exposure Monitoring among Pregnant Women with and without Asthma," IJERPH, MDPI, vol. 17(13), pages 1-16, July.
    19. Nabeela Farah & Anam Afzal & Saira Siddiqui & Naveed Farah, 2023. "Investigating Health Impact on Women Due to Domestic Cooking Fuels and Associated Social Issues in Rural Punjab," Review of Applied Socio-Economic Research, Pro Global Science Association, vol. 25(1), pages 99-111, June.
    20. Yii-Ting Huang & Chien-Chih Chen & Yu-Ni Ho & Ming-Ta Tsai & Chih-Min Tsai & Po-Chun Chuang & Fu-Jen Cheng, 2021. "Short-Term Effects of Particulate Matter and Its Constituents on Emergency Room Visits for Chronic Obstructive Pulmonary Disease: A Time-Stratified Case-Crossover Study in an Urban Area," IJERPH, MDPI, vol. 18(9), pages 1-12, April.
    21. Juha Baek & Bita A. Kash & Xiaohui Xu & Mark Benden & Jon Roberts & Genny Carrillo, 2020. "Effect of Ambient Air Pollution on Hospital Readmissions among the Pediatric Asthma Patient Population in South Texas: A Case-Crossover Study," IJERPH, MDPI, vol. 17(13), pages 1-12, July.
    22. Amirhosein Mousavi & Yiting Yuan & Shahir Masri & Greg Barta & Jun Wu, 2021. "Impact of 4th of July Fireworks on Spatiotemporal PM 2.5 Concentrations in California Based on the PurpleAir Sensor Network: Implications for Policy and Environmental Justice," IJERPH, MDPI, vol. 18(11), pages 1-18, May.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0174050. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.