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High risk of developing subsequent epilepsy in patients with sleep-disordered breathing

Author

Listed:
  • Tomor Harnod
  • Yu-Chiao Wang
  • Cheng-Li Lin
  • Chun-Hung Tseng

Abstract

Purpose: Sleep-disordered breathing (SDB) is often associated with other medical disorders. Whether SDB interacts with other factors for developing subsequent epilepsy remains unclear. Methods: This population-based cohort study was conducted using the National Health Insurance Research Database of Taiwan. Patients aged >20 years and diagnosed with SDB between 2000 and 2010 comprised the SDB cohort (n = 138,507), and their data were compared with those of the comparison cohort (n = 138,507). The adjusted hazard ratio (aHR) for epilepsy was calculated using a multivariate Cox proportional hazards model. Results: The SDB cohort had an increased risk of epilepsy (aHR = 1.50, 95% confidence interval [CI] = 1.36–1.66). The sex-stratified analysis revealed a significant adjusted hazard ratio (aHR) for epilepsy with a 1.51-fold higher risk for female patients, and also a significantly 1.49-fold higher risk for male patients in the SDB cohort. Although epilepsy incidence increased with age in both cohorts, different age groups in the SDB cohort all had a significantly higher risk of developing epilepsy than comparison cohort. Conclusion: This population-based cohort study indicates that patients with SDB are at a high risk of developing subsequent epilepsy, in both sexes and all age groups.

Suggested Citation

  • Tomor Harnod & Yu-Chiao Wang & Cheng-Li Lin & Chun-Hung Tseng, 2017. "High risk of developing subsequent epilepsy in patients with sleep-disordered breathing," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-10, March.
    • Handle: RePEc:plo:pone00:0173491
    DOI: 10.1371/journal.pone.0173491
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