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Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium

Author

Listed:
  • J M Vonk
  • S Scholtens
  • D S Postma
  • M F Moffatt
  • D Jarvis
  • A Ramasamy
  • M Wjst
  • E R Omenaas
  • E Bouzigon
  • F Demenais
  • R Nadif
  • V Siroux
  • A V Polonikov
  • M Solodilova
  • V P Ivanov
  • I Curjuric
  • M Imboden
  • A Kumar
  • N Probst-Hensch
  • L M Ogorodova
  • V P Puzyrev
  • E Yu Bragina
  • M B Freidin
  • I M Nolte
  • A M Farrall
  • W O C M Cookson
  • D P Strachan
  • G H Koppelman
  • H M Boezen

Abstract

Background: Genome-wide association studies have identified novel genetic associations for asthma, but without taking into account the role of active tobacco smoking. This study aimed to identify novel genes that interact with ever active tobacco smoking in adult onset asthma. Methods: We performed a genome-wide interaction analysis in six studies participating in the GABRIEL consortium following two meta-analyses approaches based on 1) the overall interaction effect and 2) the genetic effect in subjects with and without smoking exposure. We performed a discovery meta-analysis including 4,057 subjects of European descent and replicated our findings in an independent cohort (LifeLines Cohort Study), including 12,475 subjects. Results: First approach: 50 SNPs were selected based on an overall interaction effect at p

Suggested Citation

  • J M Vonk & S Scholtens & D S Postma & M F Moffatt & D Jarvis & A Ramasamy & M Wjst & E R Omenaas & E Bouzigon & F Demenais & R Nadif & V Siroux & A V Polonikov & M Solodilova & V P Ivanov & I Curjuric, 2017. "Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-16, March.
    • Handle: RePEc:plo:pone00:0172716
    DOI: 10.1371/journal.pone.0172716
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