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Vitamin D deficiency is significantly associated with depression in patients with chronic kidney disease

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  • Jong Hyun Jhee
  • Hyoungnae Kim
  • Seohyun Park
  • Hae-Ryong Yun
  • Su-Young Jung
  • Youn Kyung Kee
  • Chang-Yun Yoon
  • Jung Tak Park
  • Seung Hyeok Han
  • Shin-Wook Kang
  • Tae-Hyun Yoo

Abstract

Background: Depression is reported to be the most common psychological problem in patients with chronic kidney disease (CKD). Several studies have reported that lower levels of serum vitamin D are significantly associated with depression. Both vitamin D deficiency and depression are prevalent in patients with CKD, yet the relationship between these two factors remains poorly understood. This study aimed to investigate the association between vitamin D levels and depression among CKD patients. Methods: Totally, 21,257 individuals who participated in the Korean National Health and Nutrition Examination Survey (KNHANES V, VI) from 2010–2014 were screened for the study; 533 CKD patients were included. Vitamin D deficiency was defined as serum 25-hydroxyvitamin D3 [25(OH)D3] ≤10 ng/mL. Patients were divided into vitamin D deficient or sufficient groups. Depression was screened for using the Korean version of the WHO Composite International Diagnostic Interview-Short Form. The association between vitamin D deficiency and depression was evaluated by multivariate logistic regression analysis. Results: The mean participant age was 70.1±9.4 years; 262 patients (49.2%) were male. The median 25(OH)D3 level was 19.1±6.9 ng/mL. The prevalence of depression was higher in CKD patients than in the general population (14.3 vs. 11.1%, P = 0.03). Additionally, the prevalence of depression was significantly higher in CKD patients with (vs. without) vitamin D deficiency (32.5% vs. 50.0%, P

Suggested Citation

  • Jong Hyun Jhee & Hyoungnae Kim & Seohyun Park & Hae-Ryong Yun & Su-Young Jung & Youn Kyung Kee & Chang-Yun Yoon & Jung Tak Park & Seung Hyeok Han & Shin-Wook Kang & Tae-Hyun Yoo, 2017. "Vitamin D deficiency is significantly associated with depression in patients with chronic kidney disease," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0171009
    DOI: 10.1371/journal.pone.0171009
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    1. Hye-Kyung Chung & Yoonsu Cho & Sumi Choi & Min-Jeong Shin, 2014. "The Association between Serum 25-Hydroxyvitamin D Concentrations and Depressive Symptoms in Korean Adults: Findings from the Fifth Korea National Health and Nutrition Examination Survey 2010," PLOS ONE, Public Library of Science, vol. 9(6), pages 1-7, June.
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