Author
Listed:
- Xian-Fei Ding
- Li-Feng Li
- Xue-Liang Zhou
- Li-Na Guo
- Meng-Meng Dou
- Yan-Yan Chi
- Shao-Xuan Wu
- Ya-Na Zhang
- Zheng-Zheng Shan
- Yi-Jie Zhang
- Feng Wang
- Qing-Xia Fan
- Jie Zhao
- Tong-Wen Sun
Abstract
Objective: Phosphorylated mammalian target of rapamycin (p-mTOR) is a promising prognostic marker in many types of cancer. However, its survival benefit in patients with breast carcinoma remains unknown. The aim of the present study was to assess the relationship between p-mTOR expression and prognosis in breast carcinoma based on a systematic review and meta-analysis. Materials and Methods: Electronic databases (including Pubmed, Embase, ISI web of science, and Cochrane Library) were searched up to November 24, 2015. The outcome measures were hazard ratios (HRs) with 95% confidence interval (CI) for the association between the prognosis of breast carcinoma patients and p-mTOR expression. Primary end points were disease-free survival (DFS), overall survival (OS), and recurrence-free survival (RFS). Statistical analysis was performed with STATA 12.0. Results: Nine cohort studies including 3051 patients met full eligibility criteria. The pooled HRs (95% CI) for OS, DFS, and RFS were 0.84 (0.27–2.63), 0.71 (0.40–1.23), and 0.48 (0.20–1.18), respectively. Conclusions: Our findings suggested that p-mTOR overexpression was not significantly related to prognosis in breast carcinoma regarding OS and disease recurrence. Prospective studies are warranted to examine the association between p-mTOR expression and survival outcomes in breast carcinoma.
Suggested Citation
Xian-Fei Ding & Li-Feng Li & Xue-Liang Zhou & Li-Na Guo & Meng-Meng Dou & Yan-Yan Chi & Shao-Xuan Wu & Ya-Na Zhang & Zheng-Zheng Shan & Yi-Jie Zhang & Feng Wang & Qing-Xia Fan & Jie Zhao & Tong-Wen Su, 2017.
"P-mTOR Expression and Implication in Breast Carcinoma: A Systematic Review and Meta-Analysis,"
PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
Handle:
RePEc:plo:pone00:0170302
DOI: 10.1371/journal.pone.0170302
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0170302. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.