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MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis

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Listed:
  • Zhengju Ren
  • Pengwei Ren
  • Bo Yang
  • Kun Fang
  • Shangqing Ren
  • Jian Liao
  • Shengzhuo Liu
  • Liangren Liu
  • Zhufeng Peng
  • Qiang Dong

Abstract

Background: Methylenetetrahydrofolate reductase gene (MTHFR C677T and A1298C) and methionine synthase gene (MS A2756G) polymorphisms have shown an association with male infertility risk in several ethnic populations. Although several studies have evaluated these associations in Chinese populations, their small sample sizes and inconsistent outcomes have prevented strong conclusions. Therefore, the present meta-analysis was performed with published studies to evaluate the associations of the three single nucleotide polymorphisms (SNPs) and male infertility in a Chinese population. Methods: We conducted a search of PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), China biology medical literature (CBM), VIP, and Chinese literature (Wan Fang) databases up to May 31, 2016. Odds ratios (ORs) and 95% confidence intervals (95%CIs) were used to assess the strength of associations with a random-effect model or a fixed-effect model based on the heterogeneity analysis results. Sensitivity analysis was used to confirm the reliability and stability of the meta-analysis. Results: A total of nine studies, including 1,713 cases and 1,104 controls, were included in the meta-analysis. The pooled results indicated that the MTHFR C667T polymorphism was significantly associated with increased risk of male infertility in the Chinese population in the allele model (T vs. C: OR = 1.47, 95%CI = 1.32–1.63), the dominant model (TT + CT vs. CC: OR = 1.51, 95%CI = 1.30–1.77), the additive model (TT vs. CC: OR = 2.08, 95%CI = 1.68–2.58) and the recessive model (TT vs. CT+CC: OR = 1.58, 95%CI = 1.31–1.90), whereas the MTHFR A1298C and MS A2756G polymorphisms were not risk factors. There was no significant heterogeneity in any genotype contrasts among the studies. The sensitivity analysis indicated that the results of this meta-analysis were relatively stable. Conclusion: This study suggests that the MTHFR C667T polymorphism may contribute to the genetic susceptibility to male infertility in the Chinese population, whereas MTHFR A1298C and MS A2756G polymorphisms may be unrelated to male infertility. Studies with larger sample sizes and representative population-based cases and well-matched controls are needed to validate our results.

Suggested Citation

  • Zhengju Ren & Pengwei Ren & Bo Yang & Kun Fang & Shangqing Ren & Jian Liao & Shengzhuo Liu & Liangren Liu & Zhufeng Peng & Qiang Dong, 2017. "MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-15, January.
    • Handle: RePEc:plo:pone00:0169789
    DOI: 10.1371/journal.pone.0169789
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    References listed on IDEAS

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    1. Mancheng Gong & Wenjing Dong & Tingyu He & Zhirong Shi & Guiying Huang & Rui Ren & Sichong Huang & Shaopeng Qiu & Runqiang Yuan, 2015. "MTHFR 677C>T Polymorphism Increases the Male Infertility Risk: A Meta-Analysis Involving 26 Studies," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-17, March.
    2. Nishi Gupta & Saraswati Gupta & Madhukar Dama & Archana David & Geeta Khanna & Anil Khanna & Singh Rajender, 2011. "Strong Association of 677 C>T Substitution in the MTHFR Gene with Male Infertility - A Study on an Indian Population and a Meta-Analysis," PLOS ONE, Public Library of Science, vol. 6(7), pages 1-14, July.
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