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Elevated Bone Turnover Markers after Risk-Reducing Salpingo-Oophorectomy in Women at Increased Risk for Breast and Ovarian Cancer

Author

Listed:
  • Ingrid E Fakkert
  • Eveline van der Veer
  • Elske Marije Abma
  • Joop D Lefrandt
  • Bruce H R Wolffenbuttel
  • Jan C Oosterwijk
  • Riemer H J A Slart
  • Iris G Westrik
  • Geertruida H de Bock
  • Marian J E Mourits

Abstract

Background: Risk-reducing salpingo-oophorectomy (RRSO) reduces ovarian cancer risk in BRCA1/2 mutation carriers. Premenopausal RRSO is hypothesized to increase fracture risk more than natural menopause. Elevated bone turnover markers (BTMs) might predict fracture risk. We investigated BTM levels after RRSO and aimed to identify clinical characteristics associated with elevated BTMs. Methods: Osteocalcin (OC), procollagen type I N-terminal peptide (PINP) and serum C-telopeptide of type I collagen (sCTx) were measured in 210 women ≥ 2 years after RRSO before age 53. BTM Z-scores were calculated using an existing reference cohort of age-matched women. Clinical characteristics were assessed by questionnaire. Results: BTMs after RRSO were higher than age-matched reference values: median Z-scores OC 0.11, p = 0.003; PINP 0.84, p

Suggested Citation

  • Ingrid E Fakkert & Eveline van der Veer & Elske Marije Abma & Joop D Lefrandt & Bruce H R Wolffenbuttel & Jan C Oosterwijk & Riemer H J A Slart & Iris G Westrik & Geertruida H de Bock & Marian J E Mou, 2017. "Elevated Bone Turnover Markers after Risk-Reducing Salpingo-Oophorectomy in Women at Increased Risk for Breast and Ovarian Cancer," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0169673
    DOI: 10.1371/journal.pone.0169673
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