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Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment

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  • Debbie Zittema
  • Niek F Casteleijn
  • Stephan J L Bakker
  • Lianne S M Boesten
  • A A Margreeth Duit
  • Casper F M Franssen
  • Carlo A J M Gaillard
  • Ron T Gansevoort

Abstract

Background: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients have an impaired urine concentrating capacity. Increased circulating vasopressin (AVP) concentrations are supposed to play a role in the progression of ADPKD. We hypothesized that ADPKD patients have a more severely impaired urine concentrating capacity in comparison to other patients with chronic kidney disease at a similar level of kidney function, with consequently an enhanced AVP response to water deprivation with higher circulating AVP concentrations. Methods: 15 ADPKD (eGFR

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  • Debbie Zittema & Niek F Casteleijn & Stephan J L Bakker & Lianne S M Boesten & A A Margreeth Duit & Casper F M Franssen & Carlo A J M Gaillard & Ron T Gansevoort, 2017. "Urine Concentrating Capacity, Vasopressin and Copeptin in ADPKD and IgA Nephropathy Patients with Renal Impairment," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-14, January.
    • Handle: RePEc:plo:pone00:0169263
    DOI: 10.1371/journal.pone.0169263
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