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Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Clinical and Hypoxemic Childhood Pneumonia over Three Years in Central Malawi: An Observational Study

Author

Listed:
  • Eric D McCollum
  • Bejoy Nambiar
  • Rashid Deula
  • Beatiwel Zadutsa
  • Austin Bondo
  • Carina King
  • James Beard
  • Harry Liyaya
  • Limangeni Mankhambo
  • Marzia Lazzerini
  • Charles Makwenda
  • Gibson Masache
  • Naor Bar-Zeev
  • Peter N Kazembe
  • Charles Mwansambo
  • Norman Lufesi
  • Anthony Costello
  • Ben Armstrong
  • Tim Colbourn

Abstract

Background: The pneumococcal conjugate vaccine’s (PCV) impact on childhood pneumonia during programmatic conditions in Africa is poorly understood. Following PCV13 introduction in Malawi in November 2011, we evaluated the case burden and rates of childhood pneumonia. Methods and Findings: Between January 1, 2012-June 30, 2014 we conducted active pneumonia surveillance in children 75% three-dose PCV13 coverage (post). We also used multivariable time-series regression, adjusting for autocorrelation and exploring seasonal variation and alternative model specifications in sensitivity analyses. Conclusions: Thirty months after PCV13 introduction in Malawi, the health system burden and rates of the severest forms of childhood pneumonia, including hypoxemia and death, have markedly decreased.

Suggested Citation

  • Eric D McCollum & Bejoy Nambiar & Rashid Deula & Beatiwel Zadutsa & Austin Bondo & Carina King & James Beard & Harry Liyaya & Limangeni Mankhambo & Marzia Lazzerini & Charles Makwenda & Gibson Masache, 2017. "Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Clinical and Hypoxemic Childhood Pneumonia over Three Years in Central Malawi: An Observational Study," PLOS ONE, Public Library of Science, vol. 12(1), pages 1-17, January.
    • Handle: RePEc:plo:pone00:0168209
    DOI: 10.1371/journal.pone.0168209
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    References listed on IDEAS

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    1. Michela Sonego & Maria Chiara Pellegrin & Genevieve Becker & Marzia Lazzerini, 2015. "Risk Factors for Mortality from Acute Lower Respiratory Infections (ALRI) in Children under Five Years of Age in Low and Middle-Income Countries: A Systematic Review and Meta-Analysis of Observational," PLOS ONE, Public Library of Science, vol. 10(1), pages 1-17, January.
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