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The TRIAGE-ProADM Score for an Early Risk Stratification of Medical Patients in the Emergency Department - Development Based on a Multi-National, Prospective, Observational Study

Author

Listed:
  • Alexander Kutz
  • Pierre Hausfater
  • Devendra Amin
  • Adina Amin
  • Pauline Canavaggio
  • Gabrielle Sauvin
  • Maguy Bernard
  • Antoinette Conca
  • Sebastian Haubitz
  • Tristan Struja
  • Andreas Huber
  • Beat Mueller
  • Philipp Schuetz
  • for the TRIAGE study group

Abstract

Introduction: The inflammatory biomarker pro-adrenomedullin (ProADM) provides additional prognostic information for the risk stratification of general medical emergency department (ED) patients. The aim of this analysis was to develop a triage algorithm for improved prognostication and later use in an interventional trial. Methods: We used data from the multi-national, prospective, observational TRIAGE trial including consecutive medical ED patients from Switzerland, France and the United States. We investigated triage effects when adding ProADM at two established cut-offs to a five-level ED triage score with respect to adverse clinical outcome. Results: Mortality in the 6586 ED patients showed a step-wise, 25-fold increase from 0.6% to 4.5% and 15.4%, respectively, at the two ProADM cut-offs (≤0.75nmol/L, >0.75–1.5nmol/L, >1.5nmol/L, p ANOVA

Suggested Citation

  • Alexander Kutz & Pierre Hausfater & Devendra Amin & Adina Amin & Pauline Canavaggio & Gabrielle Sauvin & Maguy Bernard & Antoinette Conca & Sebastian Haubitz & Tristan Struja & Andreas Huber & Beat Mu, 2016. "The TRIAGE-ProADM Score for an Early Risk Stratification of Medical Patients in the Emergency Department - Development Based on a Multi-National, Prospective, Observational Study," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-17, December.
    • Handle: RePEc:plo:pone00:0168076
    DOI: 10.1371/journal.pone.0168076
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