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Prognostic Impact of IPSS-R and Chromosomal Translocations in 751 Korean Patients with Primary Myelodysplastic Syndrome

Author

Listed:
  • Koung Jin Suh
  • June-Won Cheong
  • Inho Kim
  • Hyeoung-Joon Kim
  • Dong-Yeop Shin
  • Youngil Koh
  • Sung-Soo Yoon
  • Yoo Hong Min
  • Jae-Sook Ahn
  • Yeo-Kyeoung Kim
  • Yun-Gyoo Lee
  • Jeong-Ok Lee
  • Soo-Mee Bang
  • Yeung-Chul Mun
  • Chu-Myoung Seong
  • Yong Park
  • Byung-Soo Kim
  • Junshik Hong
  • Jinny Park
  • Jae Hoon Lee
  • Sung-Yong Kim
  • Hong Ghi Lee

Abstract

Chromosomal translocations are rare in myelodysplastic syndrome (MDS) and their impact on overall survival (OS) and response to hypomethylating agents (HMA) is unknown. The prognostic impact of the revised International Prognostic Scoring System (IPSS-R) and for chromosomal translocations was assessed in 751 patients from the Korea MDS Registry. IPSS-R effectively discriminated patients according to leukaemia evolution risk and OS. We identified 40 patients (5.3%) carrying translocations, 30 (75%) of whom also fulfilled complex karyotype criteria. Translocation presence was associated with a shorter OS (median, 12.0 versus 79.7 months, P

Suggested Citation

  • Koung Jin Suh & June-Won Cheong & Inho Kim & Hyeoung-Joon Kim & Dong-Yeop Shin & Youngil Koh & Sung-Soo Yoon & Yoo Hong Min & Jae-Sook Ahn & Yeo-Kyeoung Kim & Yun-Gyoo Lee & Jeong-Ok Lee & Soo-Mee Ban, 2016. "Prognostic Impact of IPSS-R and Chromosomal Translocations in 751 Korean Patients with Primary Myelodysplastic Syndrome," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-17, November.
    • Handle: RePEc:plo:pone00:0166245
    DOI: 10.1371/journal.pone.0166245
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