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Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis

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  • Yulin Liu
  • Ke Wu
  • Liang Shi
  • Fan Xiang
  • Kaixiong Tao
  • Guobin Wang

Abstract

Objective: Recently, numerous studies have reported that hexokinase-2 (HK2) is aberrantly expressed in cancer, indicating that HK2 plays a pivotal role in the development and progression of cancer. However, its prognostic significance in solid tumor remains unclear. Accordingly, we performed a meta-analysis to assess the prognostic value of HK2 in solid tumor. Methods: Eligible studies were identified using PubMed, Embase, and Web of Science databases. Pooled hazard ratios (HRs) with 95% confidence intervals (CIs) for overall survival (OS) or progression-free survival (PFS)/disease-free survival (DFS)/relapse-free survival (RFS) were estimated with random effects or fixed effects models, respectively. Subgroup analysis was also performed according to patients’ ethnicities, tumor types, detection methods, and analysis types. Results: Data from 21 included studies with 2532 patients were summarized. HK2 overexpression was significantly associated with worse OS (pooled HR = 1.90, 95% CI = 1.51–2.38, p

Suggested Citation

  • Yulin Liu & Ke Wu & Liang Shi & Fan Xiang & Kaixiong Tao & Guobin Wang, 2016. "Prognostic Significance of the Metabolic Marker Hexokinase-2 in Various Solid Tumors: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(11), pages 1-13, November.
    • Handle: RePEc:plo:pone00:0166230
    DOI: 10.1371/journal.pone.0166230
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