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High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects

Author

Listed:
  • Kei Kohno
  • Hiroto Narimatsu
  • Yosuke Shiono
  • Ikuko Suzuki
  • Yuichi Kato
  • Ri Sho
  • Katsumi Otani
  • Kenichi Ishizawa
  • Hidetoshi Yamashita
  • Isao Kubota
  • Yoshiyuki Ueno
  • Takeo Kato
  • Akira Fukao
  • Takamasa Kayama

Abstract

Erythroid abnormalities including anemia and polycythemia are often observed in the general clinical setting. Because recent studies reported that adiponectin negatively affects hematopoiesis, we performed a prospective observational study to assess the relationship between anemia and adiponectin, as well as other parameters, in 1029 Japanese subjects (477 men and 552 women) 40 years of age and older. Body measurements, blood tests, and nutrition intake studies were performed at baseline, and 5 to 7 years later (follow-up). Hemoglobin (Hb) and hematocrit (Hct) levels in men with high serum adiponectin levels were lower at follow-up than at baseline. Multiple regression analysis showed that age, body mass index, adiponectin, and glutamic-pyruvic transaminase were significantly associated with erythroid-related variables (red blood cells, Hb, and Hct) in both men and women (P

Suggested Citation

  • Kei Kohno & Hiroto Narimatsu & Yosuke Shiono & Ikuko Suzuki & Yuichi Kato & Ri Sho & Katsumi Otani & Kenichi Ishizawa & Hidetoshi Yamashita & Isao Kubota & Yoshiyuki Ueno & Takeo Kato & Akira Fukao & , 2016. "High Serum Adiponectin Level Is a Risk Factor for Anemia in Japanese Men: A Prospective Observational Study of 1,029 Japanese Subjects," PLOS ONE, Public Library of Science, vol. 11(12), pages 1-14, December.
    • Handle: RePEc:plo:pone00:0165511
    DOI: 10.1371/journal.pone.0165511
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    References listed on IDEAS

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    1. Olaia Naveiras & Valentina Nardi & Pamela L. Wenzel & Peter V. Hauschka & Frederic Fahey & George Q. Daley, 2009. "Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment," Nature, Nature, vol. 460(7252), pages 259-263, July.
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