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An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China

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  • Fengdi Zhang
  • Li Liu
  • Meiyan Sun
  • Jianjun Sun
  • Hongzhou Lu

Abstract

Background: Understanding the mechanisms of drug resistance can facilitate better management of antiretroviral therapy, helping to prevent transmission and decrease the morbidity and mortality of people living with HIV/AIDS. However, there is little data about transmitted drug resistance and acquired drug resistance for HIV/AIDS patients in Shanghai. Methods: A retrospective cohort study of HIV-infected patients who visited the Department of Infectious Disease from June 2008 to June 2015 was conducted in Shanghai, China. Logistic regression analysis was performed to analyze risk factors for drug resistance among HIV-infected people with virological failure. The related collected factors included patient age, gender, marital status, infection route, baseline CD4 count, antiretroviral therapy regimens, time between HIV diagnosis and initiating antiretroviral therapy. Factors with p

Suggested Citation

  • Fengdi Zhang & Li Liu & Meiyan Sun & Jianjun Sun & Hongzhou Lu, 2017. "An analysis of drug resistance among people living with HIV/AIDS in Shanghai, China," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-11, February.
    • Handle: RePEc:plo:pone00:0165110
    DOI: 10.1371/journal.pone.0165110
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