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Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis

Author

Listed:
  • Koji M Nishiguchi
  • Yu Yokoyama
  • Yusuke Fujii
  • Kosuke Fujita
  • Yusuke Tomiyama
  • Ryo Kawasaki
  • Toshinori Furukawa
  • Fumiko Ono
  • Nobuhiro Shimozawa
  • Mutsumi Togo
  • Michihiro Suzuki
  • Toru Nakazawa

Abstract

Age-dependent formation of macular drusen caused by the focal accumulation of extracellular deposits beneath the retinal pigment epithelium precede the development of age-related macular degeneration (AMD), one of the leading causes of blindness worldwide. It is established that inflammation contributes to the pathogenesis of drusen and AMD. However, development of a preemptive therapeutic strategy targeting macular drusen and AMD has been impeded by the lack of relevant animal models because most laboratory animals lack macula, an anatomic feature present only in humans and a subset of monkeys. Reportedly, macular drusen and macular degeneration develop in monkeys in an age-dependent manner. In this study, we analyzed blood test results from 945 Macaca fascicularis, 317 with and 628 without drusen. First, a trend test for drusen frequency (the Cochran–Armitage test) was applied to the quartile data for each parameter. We selected variables with an increasing or decreasing trend with higher quartiles at P

Suggested Citation

  • Koji M Nishiguchi & Yu Yokoyama & Yusuke Fujii & Kosuke Fujita & Yusuke Tomiyama & Ryo Kawasaki & Toshinori Furukawa & Fumiko Ono & Nobuhiro Shimozawa & Mutsumi Togo & Michihiro Suzuki & Toru Nakazawa, 2016. "Analysis of Macular Drusen and Blood Test Results in 945 Macaca fascicularis," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0164899
    DOI: 10.1371/journal.pone.0164899
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