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Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study

Author

Listed:
  • Simon Endes
  • Seraina Caviezel
  • Emmanuel Schaffner
  • Julia Dratva
  • Christian Schindler
  • Nino Künzli
  • Martin Bachler
  • Siegfried Wassertheurer
  • Nicole Probst-Hensch
  • Arno Schmidt-Trucksäss

Abstract

Background and Objectives: There is a lack of evidence concerning associations between novel parameters of arterial stiffness as cardiovascular risk markers and traditional structural and functional vascular biomarkers in a population-based Caucasian cohort. We examined these associations in the second follow-up of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA 3). Methods: Arterial stiffness was measured oscillometrically by pulse wave analysis to derive the cardio-ankle vascular index (CAVI), brachial-ankle (baPWV) and aortic pulse wave velocity (aPWV), and amplitude of the forward and backward wave. Carotid ultrasonography was used to measure carotid intima-media thickness (cIMT) and carotid lumen diameter (LD), and to derive a distensibility coefficient (DC). We used multivariable linear regression models adjusted for several potential confounders for 2,733 people aged 50–81 years. Results: CAVI, aPWV and the amplitude of the forward and backward wave were significant predictors of cIMT (p

Suggested Citation

  • Simon Endes & Seraina Caviezel & Emmanuel Schaffner & Julia Dratva & Christian Schindler & Nino Künzli & Martin Bachler & Siegfried Wassertheurer & Nicole Probst-Hensch & Arno Schmidt-Trucksäss, 2016. "Associations of Novel and Traditional Vascular Biomarkers of Arterial Stiffness: Results of the SAPALDIA 3 Cohort Study," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-12, September.
    • Handle: RePEc:plo:pone00:0163844
    DOI: 10.1371/journal.pone.0163844
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