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Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials

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  • Muhan LÜ
  • Shan Yu
  • Jiaqi Deng
  • Qiong Yan
  • Chun Yang
  • Guodong Xia
  • Xian Zhou

Abstract

Background: Traditional Helicobacter pylori (H. pylori) eradication therapies have shown efficacies below 80% in several studies, and their use has been accompanied by antibiotic-related side effects. Some recent studies have reported that supplementing standard therapies with probiotics can improve the efficacy and tolerability of Helicobacter pylori eradication therapy. Objective: To assess the effects of probiotic supplementation on the eradication rates and therapy-related adverse event rates of anti-Helicobacter pylori regimens. Methods: We searched PubMed, Medline, the Cochrane Central Registry of Controlled Trials and the Chinese Biomedical Database for eligible randomized controlled trials published through July, 2015. Review Manager 5.3 was used for all statistical analyses. Results: Thirteen randomized controlled trials involving a total of 2306 patients were included in our analysis. Intent-to-treat (ITT) analysis performed using a fixed-effects model (test for heterogeneity I2 = 45%) showed that the pooled relative risk (RR) of eradication was significantly higher in the probiotic supplementation group than in the control group [RR 1.15, 95% confidence interval (CI): 1.10–1.20, P

Suggested Citation

  • Muhan LÜ & Shan Yu & Jiaqi Deng & Qiong Yan & Chun Yang & Guodong Xia & Xian Zhou, 2016. "Efficacy of Probiotic Supplementation Therapy for Helicobacter pylori Eradication: A Meta-Analysis of Randomized Controlled Trials," PLOS ONE, Public Library of Science, vol. 11(10), pages 1-26, October.
    • Handle: RePEc:plo:pone00:0163743
    DOI: 10.1371/journal.pone.0163743
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