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Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging

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  • Clémence Loiseau
  • Jacques Augenstreich
  • Adrienne Marchand
  • Etienne Harté
  • Martine Garcia
  • Julien Verdon
  • Marc Mesnil
  • Sophie Lecomte
  • Jean-Marc Berjeaud

Abstract

Antimicrobial peptides can be used as therapeutic agents against cancer cells. Warnericin RK and derivatives (WarnG20D and WarnF14V) were tested on various, solid tumor or leukemia, cancer cells. These peptides appeared to be cytotoxic on all the cell types tested, cancerous as well healthy, but very interestingly displayed no deleterious effect on healthy mononuclear cells. The mode of action of the peptide was proposed to be membranolytic, using chemical Raman imaging. Addition of peptide induced a large disorganization of the membrane leading to the loss of the content of inner compartments of Jurkat cell, whereas no effect was observed on the healthy mononuclear cells. The less hemolytic peptides WarnG20D and WarnF14V could be good candidates for the leukemia treatment.

Suggested Citation

  • Clémence Loiseau & Jacques Augenstreich & Adrienne Marchand & Etienne Harté & Martine Garcia & Julien Verdon & Marc Mesnil & Sophie Lecomte & Jean-Marc Berjeaud, 2016. "Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging," PLOS ONE, Public Library of Science, vol. 11(9), pages 1-15, September.
    • Handle: RePEc:plo:pone00:0162007
    DOI: 10.1371/journal.pone.0162007
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    1. Pachiyappan Kamarajan & Takayuki Hayami & Bibiana Matte & Yang Liu & Theodora Danciu & Ayyalusamy Ramamoorthy & Francis Worden & Sunil Kapila & Yvonne Kapila, 2015. "Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-20, July.
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