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Renal Function Impairment and Associated Factors among HAART Naïve and Experienced Adult HIV Positive Individuals in Southwest Ethiopia: A Comparative Cross Sectional Study

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  • Yewulsew Mekuria
  • Daniel Yilma
  • Zeleke Mekonnen
  • Tesfaye Kassa
  • Lealem Gedefaw

Abstract

Background: Human immunodeficiency virus (HIV) infection and its treatment cause renal diseases. Renal disease is associated with an increasing cause of morbidity and mortality in HIV positive individuals than in the general population. It has been also associated with adverse outcomes, such as complications of decreased renal functions and progression to renal failure. Objective: To determine the prevalence and factors associated with renal function impairment among highly active antiretroviral therapy (HAART) naive and HAART experienced adult HIV positive individuals. Methods: A facility based comparative cross-sectional study was conducted in Jimma University Specialized Hospital (JUSH) from June to September 2014. HIV positive individuals who visited JUSH during the study period were included in the study. Sociodemographic and clinical data were collected using a structured questionnaire. Blood specimen was analyzed for renal function tests. Descriptive statistics, Mann-Whitney U test and logistic regression analysis were done using SPSS version 16 software. Results: A total of 446 HIV positive individuals, 223 HAART naïve and 223 HAART experienced, were recruited. The overall prevalence of renal function impairment was 18.2% [95%CI: 14.6–21.7]. The prevalence of renal impairment in HAART naive and HAART experienced persons was 28.7% [95%CI: 23.1–34.4] and 7.6% [95%CI: 4.6–11.6], respectively. Age ≥ 50 years (AOR = 3.6; 95% CI 1.4, 9.6), advanced WHO stage (AOR = 2.3; 95% CI 1.1, 4.7), and CD4 count

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  • Yewulsew Mekuria & Daniel Yilma & Zeleke Mekonnen & Tesfaye Kassa & Lealem Gedefaw, 2016. "Renal Function Impairment and Associated Factors among HAART Naïve and Experienced Adult HIV Positive Individuals in Southwest Ethiopia: A Comparative Cross Sectional Study," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-11, August.
    • Handle: RePEc:plo:pone00:0161180
    DOI: 10.1371/journal.pone.0161180
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    1. Helen Bygrave & Katharina Kranzer & Katherine Hilderbrand & Guillaume Jouquet & Eric Goemaere & Nathalie Vlahakis & Laura Triviño & Lipontso Makakole & Nathan Ford, 2011. "Renal Safety of a Tenofovir-Containing First Line Regimen: Experience from an Antiretroviral Cohort in Rural Lesotho," PLOS ONE, Public Library of Science, vol. 6(3), pages 1-5, March.
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