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Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis

Author

Listed:
  • Wei Han
  • Chun-tao Shi
  • Fei-yun Cao
  • Fang Cao
  • Min-bin Chen
  • Rong-zhu Lu
  • Hua-bing Wang
  • Min Yu
  • Da-wei He
  • Qing-hua Wang
  • Jie-feng Wang
  • Xuan-xuan Xu
  • Hou-zhong Ding

Abstract

Objective: There is a heated debate on whether the prognostic value of NME1 is favorable or unfavorable. Thus, we carried out a meta-analysis to evaluate the relationship between NME1 expression and the prognosis of patients with digestive system neoplasms. Methods: We searched PubMed, EMBASE and Web of Science for relevant articles. The pooled odd ratios (ORs) and corresponding 95%CI were calculated to evaluate the prognostic value of NME1 expression in patients with digestive system neoplasms, and the association between NME1 expression and clinicopathological factors. We also performed subgroup analyses to find out the source of heterogeneity. Results: 2904 patients were pooled from 28 available studies in total. Neither the incorporative OR combined by 17 studies with overall survival (OR = 0.65, 95%CI:0.41–1.03, P = 0.07) nor the pooled OR with disease-free survival (OR = 0.75, 95%CI:0.17–3.36, P = 0.71) in statistics showed any significance. Although we couldn’t find any significance in TNM stage (OR = 0.78, 95%CI:0.44–1.36, P = 0.38), elevated NME1 expression was related to well tumor differentiation (OR = 0.59, 95%CI:0.47–0.73, P

Suggested Citation

  • Wei Han & Chun-tao Shi & Fei-yun Cao & Fang Cao & Min-bin Chen & Rong-zhu Lu & Hua-bing Wang & Min Yu & Da-wei He & Qing-hua Wang & Jie-feng Wang & Xuan-xuan Xu & Hou-zhong Ding, 2016. "Prognostic Value of NME1 (NM23-H1) in Patients with Digestive System Neoplasms: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-20, August.
    • Handle: RePEc:plo:pone00:0160547
    DOI: 10.1371/journal.pone.0160547
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