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Long-Term Adherence to IFN Beta-1a Treatment when Using RebiSmart® Device in Patients with Relapsing-Remitting Multiple Sclerosis

Author

Listed:
  • O Fernández
  • R Arroyo
  • S Martínez-Yélamos
  • M Marco
  • J A García Merino
  • D Muñoz
  • E Merino
  • A Roque
  • RELOAD Study Group

Abstract

The effectiveness of disease-modifying drugs in the treatment of multiple sclerosis is associated with adherence. RebiSmart® electronic device provides useful information about adherence to the treatment with subcutaneous (sc) interferon (IFN) β-1a (Rebif®). The aim of the study was to determine long-term adherence to this treatment in patients with relapsing-remitting multiple sclerosis (RRMS). This retrospective multicentre observational study analysed 258 patients with RRMS who were receiving sc IFN β-1a (Rebif®) treatment by using RebiSmart® until replacement (36 months maximum lifetime) or treatment discontinuation. Adherence was calculated with data (injection dosage, time, and date) automatically recorded by RebiSmart®. Patients in the study had a mean age of 41 years with a female proportion of 68%. Mean EDSS score at start of treatment was 1.8 (95% CI, 1.6–1.9). Overall adherence was 92.6% (95% CI, 90.6–94.5%). A total of 30.2% of patients achieved an adherence rate of 100%, 80.6% at least 90%, and only 13.2% of patients showed a suboptimal adherence (

Suggested Citation

  • O Fernández & R Arroyo & S Martínez-Yélamos & M Marco & J A García Merino & D Muñoz & E Merino & A Roque & RELOAD Study Group, 2016. "Long-Term Adherence to IFN Beta-1a Treatment when Using RebiSmart® Device in Patients with Relapsing-Remitting Multiple Sclerosis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-12, August.
    • Handle: RePEc:plo:pone00:0160313
    DOI: 10.1371/journal.pone.0160313
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    References listed on IDEAS

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    1. Oscar Fernández & Javier Agüera & Guillermo Izquierdo & Javier Millán-Pascual & Lluis Ramió i Torrentà & Pedro Oliva & Javier Argente & Yasmina Berdei & Jose Maria Soler & Olga Carmona & Jose Maria Er, 2012. "Adherence to Interferon β-1b Treatment in Patients with Multiple Sclerosis in Spain," PLOS ONE, Public Library of Science, vol. 7(5), pages 1-7, May.
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