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Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study

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Listed:
  • Sirous Darabian
  • Jye-Yu C Backlund
  • Patricia A Cleary
  • Nasim Sheidaee
  • Ionut Bebu
  • John M Lachin
  • Matthew J Budoff
  • DCCT/EDIC Research Group

Abstract

Introduction: Type 1 diabetes (T1DM) patients are at increased risk of coronary artery disease (CAD). This pilot study sought to evaluate the relationship between epicardial adipose tissue (EAT) and intra-thoracic adipose tissue (IAT) volumes and cardio-metabolic risk factors in T1DM. Method: EAT/IAT volumes in 100 patients, underwent non-contrast cardiac computed tomography in the Diabetes Control and Complications Trial /Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study were measured by a certified reader. Fat was defined as pixels’ density of -30 to -190 Hounsfield Unit. The associations were assessed using–Pearson partial correlation and linear regression models adjusted for gender and age with inverse probability sample weighting. Results: The weighted mean age was 43 years (range 32–57) and 53% were male. Adjusted for gender, Pearson correlation analysis showed a significant correlation between age and EAT/IAT volumes (both p

Suggested Citation

  • Sirous Darabian & Jye-Yu C Backlund & Patricia A Cleary & Nasim Sheidaee & Ionut Bebu & John M Lachin & Matthew J Budoff & DCCT/EDIC Research Group, 2016. "Significance of Epicardial and Intrathoracic Adipose Tissue Volume among Type 1 Diabetes Patients in the DCCT/EDIC: A Pilot Study," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0159958
    DOI: 10.1371/journal.pone.0159958
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