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Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer’s Disease Risk: A Meta-Analysis

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  • Hai Yuan
  • Qing Xia
  • Kang Ling
  • Xiaotong Wang
  • Xiumin Wang
  • Xunping Du

Abstract

Background: Epidemiological studies have investigated the role of choline acetyltransferase (ChAT) in Alzheimer’s disease (AD). ChAT gene polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A, and rs3810950G/A) may be associated with the risk of AD. In this meta-analysis, we determined the relationship between the four polymorphisms and the risk of AD. Methods: We searched MEDLINE, EMBASE, and HuGEnet databases for studies linking the four polymorphisms with AD risk. We included 16 articles in our meta-analysis to assess the association between the four polymorphisms and susceptibility to AD by calculating the pooled odds ratios (ORs) and 95% confidence intervals (CIs). Results: The combined results showed no significant association with rs1880676G/A and rs2177369G/A polymorphisms. The risk of AD (GG+GA versus AA: OR = 0.01, 95%CI = 0.01–0.02, P

Suggested Citation

  • Hai Yuan & Qing Xia & Kang Ling & Xiaotong Wang & Xiumin Wang & Xunping Du, 2016. "Association of Choline Acetyltransferase Gene Polymorphisms (SNPs rs868750G/A, rs1880676G/A, rs2177369G/A and rs3810950G/A) with Alzheimer’s Disease Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0159022
    DOI: 10.1371/journal.pone.0159022
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