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Long Term Clinical Prognostic Factors in Relapsing-Remitting Multiple Sclerosis: Insights from a 10-Year Observational Study

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Listed:
  • Gabriel Bsteh
  • Rainer Ehling
  • Andreas Lutterotti
  • Harald Hegen
  • Franziska Di Pauli
  • Michael Auer
  • Florian Deisenhammer
  • Markus Reindl
  • Thomas Berger

Abstract

Background: Multiple sclerosis (MS) has a highly heterogenic course making prediction of long term outcome very difficult. Objective: The objective was to evaluate current and identify additional clinical factors that are linked to long term outcome of relapsing-remitting MS assessed by disability status 10 years after disease onset. Methods: This observational study included 793 patients with relapsing-remitting MS. Clinical factors hypothesized to influence long term outcome measured by EDSS scores 10 years after disease onset were analysed by Kaplan-Meier-estimates. Multinomial logistic regression models regarding mild (EDSS ≤2.5), moderate (EDSS 3.0–5.5) or severe (EDSS ≥6.0) disability were calculated to correct for confounders. Results: Secondary progression was the strongest predictor of severe disability (Hazard ratio [HR] 503.8, 95% confidence interval [CI] 160.0–1580.1); p

Suggested Citation

  • Gabriel Bsteh & Rainer Ehling & Andreas Lutterotti & Harald Hegen & Franziska Di Pauli & Michael Auer & Florian Deisenhammer & Markus Reindl & Thomas Berger, 2016. "Long Term Clinical Prognostic Factors in Relapsing-Remitting Multiple Sclerosis: Insights from a 10-Year Observational Study," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-14, July.
    • Handle: RePEc:plo:pone00:0158978
    DOI: 10.1371/journal.pone.0158978
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