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Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection

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  • Erika Ahlgren
  • Lars Hagberg
  • Dietmar Fuchs
  • Lars-Magnus Andersson
  • Staffan Nilsson
  • Henrik Zetterberg
  • Magnus Gisslén

Abstract

Objective: To investigate the role of homocysteine in neuronal injury in HIV infection. Methods: Using a cross-sectional design and archived samples, we compared concentrations of plasma homocysteine and cerebrospinal fluid (CSF) neurofilament light protein (NFL), a sensitive marker of neuronal injury, in 83 HIV-1-infected subjects without antiretroviral treatment. We also analyzed plasma vitamin B12, serum folate, CSF, and plasma HIV RNA, the immune activation marker neopterin in CSF and serum, and albumin ratio as a marker of blood-brain barrier integrity. Twenty-two subjects provided a second sample median of 12.5 months after antiretroviral treatment initiation. Results: A significant correlation was found between plasma homocysteine and CSF NFL concentrations in untreated individuals (r = 0.52, p

Suggested Citation

  • Erika Ahlgren & Lars Hagberg & Dietmar Fuchs & Lars-Magnus Andersson & Staffan Nilsson & Henrik Zetterberg & Magnus Gisslén, 2016. "Association between Plasma Homocysteine Levels and Neuronal Injury in HIV Infection," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0158973
    DOI: 10.1371/journal.pone.0158973
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