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Retinal Vessel Analysis (RVA) in the Context of Subarachnoid Hemorrhage - A Proof of Concept Study

Author

Listed:
  • Walid Albanna
  • Catharina Conzen
  • Miriam Weiss
  • Hans Clusmann
  • Matthias Fuest
  • Marguerite Mueller
  • Marc Alexander Brockmann
  • Walthard Vilser
  • Arno Schmidt-Trucksäss
  • Anke Hoellig
  • Marcel Seiz
  • Claudius Thomé
  • Konstantin Kotliar
  • Gerrit Alexander Schubert

Abstract

Background: Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. Methods: In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2–14) and eight patients at the time of follow-up (mean 4.6±1.7months after SAH), and included 33 age-matched healthy controls. Data was acquired using a manoeuvrable Dynamic Vessel Analyzer (Imedos Systems UG, Jena) for examination of retinal vessel dimension and neurovascular coupling. Results: Image quality was satisfactory in the majority of cases (93.3%). In the acute phase after SAH, retinal arteries were significantly dilated when compared to the control group (124.2±4.3MU vs 110.9±11.4MU, p

Suggested Citation

  • Walid Albanna & Catharina Conzen & Miriam Weiss & Hans Clusmann & Matthias Fuest & Marguerite Mueller & Marc Alexander Brockmann & Walthard Vilser & Arno Schmidt-Trucksäss & Anke Hoellig & Marcel Seiz, 2016. "Retinal Vessel Analysis (RVA) in the Context of Subarachnoid Hemorrhage - A Proof of Concept Study," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-13, July.
    • Handle: RePEc:plo:pone00:0158781
    DOI: 10.1371/journal.pone.0158781
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