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The Use of Immunosuppressant Therapy for Multiple Sclerosis in Italy: A Multicenter Retroprospective Study

Author

Listed:
  • Emanuele D’Amico
  • Carmela Leone
  • Giusi Graziano
  • Maria Pia Amato
  • Roberto Bergamaschi
  • Paola Cavalla
  • Gabriella Coniglio
  • Giancarlo Di Battista
  • Maria Teresa Ferrò
  • Franco Granella
  • Enrico Granieri
  • Alessandra Lugaresi
  • Giacomo Lus
  • Enrico Millefiorini
  • Carlo Pozzilli
  • Gioacchino Tedeschi
  • Mario Zappia
  • Giancarlo Comi
  • Maria Trojano
  • Vito Lepore
  • Francesco Patti

Abstract

Introduction: Immunosuppressive agents (ISA) have been used in multiple sclerosis (MS) for decades, frequently as off label licensed therapies. Given the new MS treatment landscape, what place do ISA have in combating MS? Methods: We conducted a retrospective multicentre study to investigate the frequency of ISA prescription in 17 Italian MS centres, and to describe the clinical factors related to ISA use. Results: Out of 6,447 MS patients, 2,034 (31.6%) were treated with ISA, with Azathioprine being the most frequently used ISA overall. MS patients treated with ISA alone were more frequently affected by the progressive course (both primary and secondary) of the disease (RRR 5.82, 95% CI 4.14–8.16, p

Suggested Citation

  • Emanuele D’Amico & Carmela Leone & Giusi Graziano & Maria Pia Amato & Roberto Bergamaschi & Paola Cavalla & Gabriella Coniglio & Giancarlo Di Battista & Maria Teresa Ferrò & Franco Granella & Enrico G, 2016. "The Use of Immunosuppressant Therapy for Multiple Sclerosis in Italy: A Multicenter Retroprospective Study," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-11, June.
    • Handle: RePEc:plo:pone00:0157721
    DOI: 10.1371/journal.pone.0157721
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