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Predictors of RSV LRTI Hospitalization in Infants Born at 33 to 35 Weeks Gestational Age: A Large Multinational Study (PONI)

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Listed:
  • Zbyněk Straňák
  • Elie Saliba
  • Paraskevi Kosma
  • Klara Posfay-Barbe
  • Khalid Yunis
  • Teresa Farstad
  • Kristina Unnebrink
  • Jean van Wyk
  • Colleen Wegzyn
  • Gerard Notario
  • Stefanie Kalus
  • Fiona J Campbell

Abstract

Background: Preterm infants are at high risk of developing respiratory syncytial virus (RSV)-associated lower respiratory tract infection (LRTI). This observational epidemiologic study evaluated RSV disease burden and risk factors for RSV-associated LRTI hospitalization in preterm infants 33 weeks+0 days to 35 weeks+6 days gestational age not receiving RSV prophylaxis. Methods: Preterm infants ≤6 months of age during RSV season (1 October 2013–30 April 2014) were followed at 72 sites across 23 countries from September 2013–July 2014 (study period). RSV testing was performed according to local clinical practice. Factors related to RSV-associated hospitalization for LRTI were identified using multivariable logistic regression with backward selection. Results: Of the 2390 evaluable infants, 204 and 127 were hospitalized for LRTI during the study period and RSV season, respectively. Among these subjects, 64/204 and 46/127, respectively, were hospitalized for confirmed RSV LRTI. Study period and RSV season normalized RSV hospitalization rates (per 100 infant years) were 4.1 and 6.1, respectively. Factors associated with an increased risk of RSV-related LRTI hospitalization in multivariable analyses were smoking of family members (P

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  • Zbyněk Straňák & Elie Saliba & Paraskevi Kosma & Klara Posfay-Barbe & Khalid Yunis & Teresa Farstad & Kristina Unnebrink & Jean van Wyk & Colleen Wegzyn & Gerard Notario & Stefanie Kalus & Fiona J Cam, 2016. "Predictors of RSV LRTI Hospitalization in Infants Born at 33 to 35 Weeks Gestational Age: A Large Multinational Study (PONI)," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-15, June.
    • Handle: RePEc:plo:pone00:0157446
    DOI: 10.1371/journal.pone.0157446
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    References listed on IDEAS

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    1. Maarten O Blanken & Hendrik Koffijberg & Elisabeth E Nibbelke & Maroeska M Rovers & Louis Bont & on behalf of the Dutch RSV Neonatal Network, 2013. "Prospective Validation of a Prognostic Model for Respiratory Syncytial Virus Bronchiolitis in Late Preterm Infants: A Multicenter Birth Cohort Study," PLOS ONE, Public Library of Science, vol. 8(3), pages 1-6, March.
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