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Predictive Factors for Efficacy and Safety of Prophylactic Theophylline for Extubation in Infants with Apnea of Prematurity

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  • Tomoko Kondo
  • Yuki Kondo
  • Yuji Orita
  • Fumi Mitarai
  • Yoichi Ishitsuka
  • Mitsuru Irikura
  • Yoshihiro Shimodozono
  • Tsutomu Douchi
  • Yasuo Takeda
  • Tetsumi Irie

Abstract

Purpose: This study aimed to evaluate predictive factors involved in efficacy and safety in Japanese infants who received theophylline therapy to prevent apnea of prematurity (AOP) after weaning from mechanical ventilation. Methods: We retrospectively reviewed the medical records of infants who were administered intravenous aminophylline (theophylline ethylenediamine) for AOP at the neonatal intensive care unit, Kagoshima University Hospital, Japan, between January 2009 and June 2013. Results: A total of 100 infants were evaluated as two separate groups in terms of efficacy and safety of theophylline. Sixty-seven (67.0%) infants had effective theophylline therapy. Multivariate logistic regression analysis showed that gestational age at birth was significant, with an odds ratio of 0.59 (p

Suggested Citation

  • Tomoko Kondo & Yuki Kondo & Yuji Orita & Fumi Mitarai & Yoichi Ishitsuka & Mitsuru Irikura & Yoshihiro Shimodozono & Tsutomu Douchi & Yasuo Takeda & Tetsumi Irie, 2016. "Predictive Factors for Efficacy and Safety of Prophylactic Theophylline for Extubation in Infants with Apnea of Prematurity," PLOS ONE, Public Library of Science, vol. 11(7), pages 1-9, July.
    • Handle: RePEc:plo:pone00:0157198
    DOI: 10.1371/journal.pone.0157198
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