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Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents

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  • Danieli Zuntini Viscardi
  • Jucicléia da Silva Arrigo
  • Camila de Azevedo Chaves Correia
  • Cândida Aparecida Leite Kassuya
  • Claudia Andrea Lima Cardoso
  • Iriani Rodrigues Maldonade
  • Eliana Janet Sanjinez Argandoña

Abstract

Campomanesia adamantium (Myrtaceae) is popularly known as “gabiroba” and has been used in folk medicine as antirheumatic, antidiarrheal, hypocholesterolemic and anti-inflammatory. This study evaluated the anti-inflammatory and antinociceptive activities and toxicology of essential oils from peel (EOP) and seed (EOS) of C. adamantium fruits in animal models. Different groups were treated with doses of 100 and 300 mg/kg and the inflammatory parameters were evaluated in carrageenan induced paw oedema and leukocyte migration in pleurisy model, while antinociceptive activity was evaluated using formalin method in rodents. The major constituent of EOP and EOS was limonene with 13.07% and 20.89%, respectively. No clinical signs of toxicity have been observed in animals. It was observed a significant decreased (P

Suggested Citation

  • Danieli Zuntini Viscardi & Jucicléia da Silva Arrigo & Camila de Azevedo Chaves Correia & Cândida Aparecida Leite Kassuya & Claudia Andrea Lima Cardoso & Iriani Rodrigues Maldonade & Eliana Janet Sanj, 2017. "Seed and peel essential oils obtained from Campomanesia adamantium fruit inhibit inflammatory and pain parameters in rodents," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-15, February.
    • Handle: RePEc:plo:pone00:0157107
    DOI: 10.1371/journal.pone.0157107
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