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Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy

Author

Listed:
  • Kristian Hillert Winther
  • Per Cramon
  • Torquil Watt
  • Jakob Bue Bjorner
  • Ola Ekholm
  • Ulla Feldt-Rasmussen
  • Mogens Groenvold
  • Åse Krogh Rasmussen
  • Laszlo Hegedüs
  • Steen Joop Bonnema

Abstract

Background: Hypothyroidism is often diagnosed, and subsequently treated, due to health-related quality of life (HRQL) issues. However, HRQL following treatment has never previously been assessed in longitudinal descriptive studies using validated instruments. Objective: To investigate disease-specific (ThyPRO) and generic (SF-36) HRQL, following levothyroxine therapy in patients with hypothyroidism due to autoimmune thyroiditis. Methods: This prospective cohort study was set at endocrine outpatient clinics at two Danish university hospitals. Seventy-eight consecutive patients were enrolled and completed HRQL questionnaires before, six weeks, and six months after initiation of levothyroxine therapy. Normative ThyPRO (n = 739) and SF-36 (n = 6,638) data were available for comparison and changes in HRQL following treatment were estimated and quantified. Results: Prior to treatment, all ThyPRO scales were significantly impacted (p

Suggested Citation

  • Kristian Hillert Winther & Per Cramon & Torquil Watt & Jakob Bue Bjorner & Ola Ekholm & Ulla Feldt-Rasmussen & Mogens Groenvold & Åse Krogh Rasmussen & Laszlo Hegedüs & Steen Joop Bonnema, 2016. "Disease-Specific as Well as Generic Quality of Life Is Widely Impacted in Autoimmune Hypothyroidism and Improves during the First Six Months of Levothyroxine Therapy," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-12, June.
    • Handle: RePEc:plo:pone00:0156925
    DOI: 10.1371/journal.pone.0156925
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