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GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas

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  • Toshiaki Haraguchi
  • Hiroaki Miyoshi
  • Koji Hiraoka
  • Shintaro Yokoyama
  • Yukinao Ishibashi
  • Toshihiro Hashiguchi
  • Koutaro Matsuda
  • Tetsuya Hamada
  • Takahiro Okawa
  • Naoto Shiba
  • Koichi Ohshima

Abstract

Objective: Recent studies have investigated the significance of GATA3 expression in patients with various malignant tumors. However, no previous studies have evaluated the clinicopathological importance of GATA3 expression in soft tissue sarcomas (STS) patients. Methods: We evaluated GATA3 expression in 76 STS cases using immunohistochemical analysis, and statistically compared clinicopathological characteristics between GATA3-positive and GATA3-negative cases. Result: GATA3-positive expression was significantly associated with a higher mitotic count (P

Suggested Citation

  • Toshiaki Haraguchi & Hiroaki Miyoshi & Koji Hiraoka & Shintaro Yokoyama & Yukinao Ishibashi & Toshihiro Hashiguchi & Koutaro Matsuda & Tetsuya Hamada & Takahiro Okawa & Naoto Shiba & Koichi Ohshima, 2016. "GATA3 Expression Is a Poor Prognostic Factor in Soft Tissue Sarcomas," PLOS ONE, Public Library of Science, vol. 11(6), pages 1-14, June.
    • Handle: RePEc:plo:pone00:0156524
    DOI: 10.1371/journal.pone.0156524
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